imagen animada PEDECIBA
Investigadores :

Página personal del Dr. Juan J. Calvete Chornet


http://www.rau.edu.uy/pedeciba/personas/calvetj.htm

Curriculum electrónico basado en CvLac-Lattes para investigadores del PEDECIBA

El Dr. Juan J. Calvete es investigador Grado 5 en el Area Biología del PEDECIBA. Ingresó al Programa en 2001. Desempeña sus actividades en el Instituto de Biomedicina de Valencia, España.

Línea de investigación:

  • Determinación de la estructura covalente de proteínas: degradación de Edman y espectrometría de masas
  • Correlaciones estructura-función de proteínas: biología molecular y cristalografía de rayos X

    Dirección postal :
    Instituto de Biomedicina de Valencia, C.S.I.C.
    Jaime Roig, 11
    46010 Valencia
    España
    Tel: +34 96 339 1775
    Fax: + 34 96 369 0800
    e-mail :jcalvete@ibv.csic.es



  • Publicaciones representativas


    • Gasset M, Saiz JL, Laynez J, Sanz L, Gentzel M, Töpfer-Petersen E, Calvete JJ
      Conformational features and thermal stability of PDC-109 oligomers and phosphorylcholine-bound complexes
      Eur J Biochem, 250: 735-744 (1997)

    • Romão MJ, Kölln I, Dias JM, Carvalho AL, Romero A, Varela PF, Sanz L, Töpfer-Petersen E, Calvete JJ
      Crystal structure of acidic seminal fluid protein (aSFP) at 1.9 Å resolution: a bovine polypeptide of the spermadhesin family
      J Mol Biol, 274: 650-660 (1997)

    • Sanz-Aparicio J, Hermoso J, GrangeiroTB, Calvete JJ, Cavada BS
      The crystal structure of Canavalia brasiliensis lectin suggests a correlation between its quaternary conformation and its distinct biological properties from Concanavalin A
      FEBS Lett, 405: 114-118 (1997)

    • Romero A, Romão MJ, Varela PF, Kölln I, Dias JM, Carvalho AL, Sanz L, Töpfer-Petersen E, Calvete JJ
      The crystal structures of two members of the spermadhesin family reveal the folding of the CUB domain Nature Struc Biol, 4: 783-788 (1997)

    • Calvete JJ, Schrader M, Raida M, McLane MA, Romero A, Niewiarowski S
      The disulphide bond pattern of bitistatin, a disintegrin isolated from the venom of the viper Bitis arietans
      FEBS Lett, 416: 197-202 (1997)

    • Varela PF, Romero A, Sanz L, Romão MJ, Töpfer-Petersen E, Calvete JJ
      The 2.4 Å resolution crystal structure of boar seminal plasma PSP-I/PSP-II: a zona pellucida-binding glycoprotein heterodimer of the spermadhesin family built by a CUB domain architecture
      J Mol Biol, 274: 635-649 (1997)

    • Calvete JJ, Santos CF, Mann K, Grangeiro TB, Nimtz M, Urbanke C, Cavada BS
      Amino acid sequence, glycan structure, and proteolytic processing of the lectin of Vatairea macrocarpa seeds
      FEBS Lett, 425: 286-292 (1998)

    • Fernández-Catalán C, Bode W, Huber R, Turk D, Calvete JJ, Lichte A, Tschesche H, Maskos K
      Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor
      EMBO J, 17: 5238-5248 (1998)

    • Dias JM, Than ME, Humm A, Huber R, Bourenkov GP, Bartunik HD, Bursakov S, Calvete JJ, Caldeira J, Carneiro C, Moura JJG, Moura I, Romão MJ
      Crystal structure of the first dissimilatory nitrate reductase at 1.9 Å solved by MAD methods
      Structure, 7: 65-79 (1999)

    • Marcinkiewicz C, Calvete JJ, Marcinkiewicz MM, Raida M, Vijay-Kumar S, Huang Z, Lobb RR, Niewiarowski S
      EC3, a novel heterodimeric disintegrin from Echis carinatus venom, inhibits a4 and a5 integrins in an RGD-independent manner
      J Biol Chem, 274: 12468-12473 (1999)

    • Rodríguez-Martínez H, Iborra A, Martínez P, Calvete JJ
      Immunoelectronmicroscopic imaging of spermadhesin AWN epitopes on boar spermatozoa bound in vivo to the zona pellucida
      Repr Fertil Dev, 10: 491-497 (1999)

    • Calvete JJ
      Platelet integrin GPIIb/IIIa: structure-function correlations. An update and lessons from other integrins
      Proc Soc Exp Biol Med, 222: 29-38 (1999)

    • Marcinkiewicz C, Calvete JJ, Vijay-Kumar S, Marcinkiewicz MM, Raida M, Schick P, Lobb RR, Niewiarowski S
      Structural and functional characterization of EMF10, a heterodimeric disintegrin from Eristocophis macmahoni venom that selectively inhibits a5b1 integrin
      Biochemistry, 38: 13302-13309 (1999)

    • Nimtz M, Grabenhorst E, Conradt HS, Sanz L, Calvete JJ
      Structural characterisation of the oligosaccharide chains of native and crystallised boar seminal plasma spermadhesin PSP-I and PSP-II glycoforms
      Eur J Biochem, 265: 703-718 (1999)

    • Wierzbicka-Patinowski I, Niewiarowski S, Marcinkiewicz C, Calvete JJ, Marcinkiewicz MM, McLane MA
      Structural requirements of echistatin for the recognition of avb3 and a5b1 integrins
      J Biol Chem, 274: 37809-37814 (1999)

    • Medeiros A, Bianchi S, Calvete JJ, Balter H, Bay S, Robles A, Cantacuzène D, Nimtz M, Alzari PM, Osinaga E
      Biochemical and functional characterization of the Tn-specific lectin from Salvia sclarea seeds
      Eur J Biochem, 267: 1434-1440 (2000)

    • Gasset M, Magdaleno L, Calvete JJ
      Biophysical study of the perturbation of model membrane structure caused by seminal plasma protein PDC-109
      Arch. Biochem. Biophys. 374 (2000) 241-247

    • Calvete JJ, Jürgens M, Marcinkiewicz C, Romero A, Schrader M, Niewiarowski S
      Disulphide bond pattern and molecular modelling of the dimeric disintegrin EMF-10, a potent and selective integrin a5b1 antagonist from Eristocophis macmahoni venom
      Biochem J, 345: 573-581 (2000)

    • Marcinkiewicz C, Taooka Y, Yokosaki Y, Calvete JJ, Marcinkiewicz MM, Lobb RR, Niewiarowski S, Sheppard D
      Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of integrin a9b1 with VCAM-1, tenascin-C and osteopontin
      J Biol Chem, 275: 31930-31937 (2000)

    • Calvete JJ, Moreno-Murciano MP, Sanz L, Jürgens M, Schrader M, Raida M, Benjamin DC, Fox JW
      The disulphide bond pattern of catrocollastatin C, a disintegrin-like/ cysteine-rich protein isolated from Crotalus atrox venom
      Protein Sci, 9: 1365-1373 (2000)