imagen animada PEDECIBA
Investigadores :

Página personal del Dr. Hugo Cerecetto


http://www.rau.edu.uy/pedeciba/personas/cerecett.htm

El Dr. Hugo Cerecetto es investigador Grado 5 en el Area Química del PEDECIBA. Ingresó al Programa en 1994. Desempeña sus actividades en la Cátedra de Química Orgánica, Facultad de Química.

Dirección postal:
Cátedra de Química Orgánica
Facultad de Química
Universidad de la República
Av. Gral. Flores 2124
Montevideo 11800
Uruguay
tel:: (+598 2) 924 1908 y 525 8618 int. 213
fax: (+598 2) 924 1906
e-mail: hcerecet@fq.edu.uy



Publicaciones


  • Monge A, Aldana I, Cerecetto H, Rivero A, Del Barrio A, Perez R, Portillo M, Martinez A
    New perhydro-1,4-oxazine derivatives of arylethanolamine with beta3-adrenoceptor agonist activity
    Pharmazie, 50: 768-769 (1995)

  • Monge A, Aldana I, Cerecetto H, Rivero A
    Synthesis of new oxazolidine, oxazolidin-2-one and perhydro-1,4-oxazine derivatives of arylethanolamine as potential beta3-adrenoceptor agonists
    J Heterocyclic Chem, 32: 1429-1432 (1995)

  • Caracelli I, Stamato FM, Mester B, Paulino M, Cerecetto H
    A new analogue of nifurtimox
    Acta Crystallogr C, 52: 1281-1282 (1996)

  • Cerecetto H, Di Maio R, González M, Seoane G
    Preparation of enamines from the condensation of glycine esters with nitro-heterocyclic aldehydes
    Heterocycles, 45: 2023 (1997)

  • Olea-Azar C, Atria AM, Mendizábal F, Di Maio R, Seoane G, Cerecetto H
    Cyclic voltammetry and electron paramagnetic resonance studies of some analogues of nifurtimox
    Spectrosc Lett, 31-1: 99-109 (1998)

  • Seoane G, Di Maio R, Cerecetto H, Ibarruri G, Denicola A, Quijano C, Paulino M
    New nitrofuran and nitrotiofene semicarbazone derivatives with potential antiparasitic activities
    Farmaco, 53: 89-94 (1998)

  • Cerecetto H, Di Maio R, Ibarruri G, Seoane G, Denicola A, Peluffo G, Quijano C, Paulino M
    Synthesis and anti-trypanosomal activity of novel 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives
    Farmaco, 53: 89-94 (1998)

  • Monge A, Lopez de Cerain A, Ezpeleta O, Cerecetto H, Dias E, Di Maio R, Gonzalez M, Onetto S, Seoane G, Suescun L, Mariezcurrena R
    Synthesis and biological evaluation of 1,2,5-oxadiazole N-oxide derivatives as hypoxia-selective cytotoxins
    Pharmazie, 53: 758-764 (1998)

  • Cerecetto H, Di Maio R, Gonzalez M, Risso M, Saenz P, Seoane G, Denicola A, Peluffo G, Quijano C, Olea-Azar C
    1,2,5-Oxadiazole N-oxide derivatives and related compounds as potential antitrypanosomal drugs: structure-activity relationships
    J Med Chem, 42(11): 1941-50 (1999)

  • Di Maio R, Cerecetto H, Seoane G, Ochoa C, Aran VJ, Perez E, Gomez Barrio A, Muelas S
    Synthesis and antichagasic properties of new 1,2,6-thiadiazin-3,5-dione 1,1-dioxides and related compounds
    Arzneimittelforschung, 49(9): 759-63 (1999)

  • Boiani M, Cerecetto H, Gonzalez M et al.
    Chemical modifications of 1,2,5-oxadiazole N-oxide system searching for cytotoxic selective hypoxic drugs
    Molecules, 5(3): 520-521 (2000)

  • Cerecetto H, Di Maio R, Gonzalez M et al.
    Nuclear magnetic resonance for the structural study of bioactive semicarbazones
    Molecules, 5(3): 420-421 (2000)

  • Cerecetto H, Gonzalez M, Saenz P et al.
    Reactivity studies of 5,6-dimethyl- and 3,5,6-trimethyl-1,2,4-triazine-N-4-oxide against different electrophiles
    Molecules, 5(3): 501-502 (2000)

  • Cerecetto H, Di Maio R, Gonzalez M, Risso M, Sagrera G, Seoane G, Denicola A, Peluffo G, Quijano C, Stoppani AO, Paulino M, Olea-Azar C, Basombrio MA
    Synthesis and antitrypanosomal evaluation of E-isomers of 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives. Structure-activity relationships
    Eur J Med Chem, 35(3): 343-50 (2000)

  • Cerecetto H, Gonzalez M, Risso M, Seoane G, Lopez de Cerain A, Ezpeleta O, Monge A, Suescun L, Mombru A, Bruno AM
    Synthesis and biological evaluation of 1,2,5-oxadiazole N-oxide derivatives as potential hypoxic cytotoxins and DNA-binders
    Arch Pharm (Weinheim), 333(11): 387-93 (2000)

  • Cerecetto H, Dias E, Di Maio R, Gonzalez M, Pacce S, Saenz P, Seoane G, Suescun L, Mombru A, Fernandez G, Lema M, Villalba J
    Synthesis and herbicidal activity of N-oxide derivatives
    J Agric Food Chem, 48(7): 2995-3002 (2000)

  • Cerecetto H, Di Maio R, Seoane G et al.
    Synthesis of 1,2,6-thiadiazin 1,1-dioxide derivatives as trypanocidal agents
    Molecules, 5(3): 499-500 (2000)

  • Cerecetto H, Di Maio R, Seoane G et al.
    Synthetic modifications of lead compounds as antitrypanosomal drugs
    Molecules, 5(3): 497-498 (2000)

  • Martinez-Merino V, Cerecetto H
    CoMFA-SIMCA model for antichagasic nitrofurazone derivatives
    Bioorg Med Chem, 9(4): 1025-30 (2001)

  • Muelas S, Di Maio R, Cerecetto H, Seoane G, Ochoa C, Escario JA, Gomez-Barrio A
    New thiadiazine derivatives with activity against Trypanosoma cruzi amastigotes
    Folia Parasitol (Praha), 48(2): 105-8 (2001)

  • Cerecetto H, González M
    N-oxides as hypoxia selective cytotoxins
    Minireview in Medicinal Chemistry, 1: 219 (2001)

  • Cerecetto H, González M, Onetto S, Risso M, Saenz P, Seoane G, Monge A, López de Ceráin A, Ezpeleta O, Olea-Azar C, Bruno AM
    1,2,4-triazine N-oxide and di-N-oxide derivatives. Synthesis and evaluation as hypoxia selective cytotoxins
    Med Chem Res, 10: 328 (2001)

  • Boiani M, Cerecetto H, Gonzalez M, Risso M, Olea-Azar C, Piro OE, Castellano EE, Lopez de Cerain A, Ezpeleta O, Monge-Vega A
    1,2,5-Oxadiazole N-oxide derivatives as potential anti-cancer agents: synthesis and biological evaluation. Part IV
    Eur J Med Chem, 36(10): 771-82 (2001)

  • Aguirre G, Cerecetto H, Di Maio R, Gonzalez M, Porcal W, Seoane G, Ortega MA, Aldana I, Monge A, Denicola A
    Benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives as potential antitrypanosomal drugs. Structure-activity relationships. Part II
    Arch Pharm (Weinheim), 335(1): 15-21 (2002)

  • Gambino D, Parajon-Costa BS, Cerecetto H. et al
    Characterization of [ReO(tetramethylthiourea)(4)](PF6)(3) in solution: electrochemical, NMR and ligand substitution studies
    J Coord Chem, 55: 1441-1453 (2002)

  • Cerecetto H, González M
    Chemotherapy of Chagas' disease: status and new developments
    Curr Top Med Chem, 2: 1185-1211 (2002)

  • Otero L, Noblia P, Gambino D, Cerecetto H, González M, Monge-Vega A, López de Ceráin A, Ezpeleta O, Parajón-Costa B
    Ruthenium semicarbazone complexes as potential antitumoral agents
    Metal Ions in Biology and Medicine, 7: 609 (2002)

  • Olea-Azar C, Rigol C, Mendizabal F, et al.
    Electrochemical and microsomal production of free radicals from 1,2,5-oxadiazole N-oxide as potential antiprotozoal drugs
    Spectrochim Acta A, 59(1): 69-74 (2003)

  • Olea-Azar C,Rigol C, Mendizabal F, Morello A, Maya JD, Mocanda C, Cabrera E, Di Maio R, González M, Cerecetto H
    ESR spin trapping studies of free radicals generated from nitrofuran derivatives analogues of nifurtimox by electrochemical and Trypanosoma cruzi reduction
    Free Radic Res (2003) (en prensa)

  • Otero L, Noblia P, Gambino D et al.
    New rhenium(V) nitrofuryl semicarbazone complexes. Crystal structure of [ReOCl2(PPh3)(3-(5-nitrofuryl)acroleine semicarbazone)]
    Z Anorg Allg Chem, 629(6): 1033-1038 (2003)

  • Cerecetto H, González M, Onetto S, Sáenz P, Ezpeleta O, López de Ceráin A, Monge A
    1,2,4-triazine N-oxide derivatives: studies as potential hypoxic cytotoxins. Part II
    Arch Pharm (2003) (en prensa)

  • Otero L, Noblia P, Gambino D, Cerecetto H, González M, Di Maio R, Ellena J, Piro OE
    Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease
    Inorg Chim Acta, 344: 85-94 (2003)