imagen animada PEDECIBA
Investigadores :

Página personal del Dr. Rodolfo Silveira


http://www.rau.edu.uy/pedeciba/personas/silveira.htm

El Dr. Rodolfo Silveira es investigador Asociado al Area Biología del PEDECIBA. Ingresó al Programa en 1987. Desempeña sus actividades en el Laboratorio Celsius, Montevideo, Uruguay.

Línea de investigación:

  • Acciones centrales y periféricas de sustancias neuroactivas de origen natural: estudios comportamentales bioquímicos y farmacológicos
  • Dirección postal:
    Laboratorio Celsius S.A.
    Joaquín Suárez 3593
    tel: (598 2) 3365446
    fax: (598 2) 3367160
    Montevideo
    Uruguay
    E-mail: rodolfo.silveira@celsius.com.uy



    Publicaciones


    • Silveira R, Barbeito L, Dajas F
      Behavioral and neurochemical effects of intraperitoneally injected dendrotoxin
      Toxicon, 26: 287-292 (1988)

    • Dajas F, Cerveñansky C, Silveira R, Barbeito L
      Fasciculins: some aspects of their anticholinesterase activity in the central nervous system
      In: Neurotoxins in Neurochemistry. O. Dolly, ed. Ellis Horwood Ltd Int Publishers in Science and Technology, pp. 241 (1988)

    • Silveira R, Siciliano JC, Abó MV, Viera L, Dajas F
      Intrastriatal dendrotoxin injection: behavioral and neurochemical effects
      Toxicon, 26: 1009-1015 (1988)

    • Dajas F, Abó MV, Viera L, Silveira R
      Effects of local inhibition of Locus coeruleus acetylcholinesterase by Fasciculin
      Neurosci Lett, 98: 253 (1989)

    • Quillfeldt J, Raskovsky S, Dalmaz C, Dias M, Huang C, Netto CA, Schneider F, Izquierdo I, Medina JH, Silveira R, Dajas F
      Bilateral injection of Fasciculin into the amygdala of rats: effects of two avoidance tasks, acetilcholinesterase activity and cholinergic muscarinic receptors
      Pharmacol Biochem Behav, 37: 439-444 (1990)

    • Wolfman C, Abó MV, Calvo D, Medina J, Dajas F, Silveira R
      Evidences of central noradrenergic recovery after one year DSP4 induced neurotoxic denervation
      Neurochem Int (1991)

    • Stockert M, Silveira R, Zieher L, Dajas F, Medina J
      Down regulation of cerebral cortical 3H imipramine binding sites during chronic antidepressant treatment is independent of the central serotonergic innervation
      J Recept Res, 12-2: 131-147 (1992)

    • Dajas F, Silveira R, Cerveñansky C
      Fasciculin: neuropharmacology of a potent anticholinesterase polypeptide
      In: M. Conn (Eds.), Methods in Neurosciences, 8: 258-270 New York Academic Press (1992)

    • Silveira R, Stjernschantz J
      Vascular effects of acetylcholinesterase inhibitors in the rabbit eye: a study with fasciculin and physostigmine
      J Occul Pharmacol, 8-2: 129-137 (1992)

    • Silveira R, Herrera-Marschitz M, Meana M, Coiny M, O'Connor W, You ZB, Ungerstedt U
      Characterization of striatal glutamate aspartate, GABA, acetylcholine and dopamine release monitored in rat with in vivo microdialysis
      Amino Acids, 5-1: 167 (1993)

    • Dajas F, Silveira R, Costa G, Castelló ME, Jerusalinsky D, Medina J, Levesque D, Greenfield S
      Differential cholinergic and non-cholinergic actions of acetylcholinesterase in the substantia nigra revealed by fasciculin-induced inhibition
      Brain Res, 616: 1-5 (1993)

    • Monti J, Jantos H, Silveira R, Reyes M, Scorza C, Prunell G
      Depletion of brain serotonin by 5,7-DHT: effects on the 8-OH-DPAT-induced changes of sleep and waking in the rat
      Psychopharmacology, 115: 273-277 (1994)

    • Reyes M, Scorza MC, Silveira R, Dajas F, Cassels BK
      Four-dimethylaminophenethylamine, a sensitive, specific, electrochemically detectable monoamine oxidase-B substrate
      Life Sci, 54: 1955-1963 (1994)

    • Loidl CF, Herrera-Marschitz M, Andersson K, You ZB, Goiny M, O'Connor WT, Silveira R, et al.
      Long-term effects of perinatal asphyxia on basal ganglia neurotransmitter systems studied with microdialysis in rat
      Neurosci Lett, 175: 9-12 (1994)

    • Reyes M, Scorza MC, Dajas F, Costa G, Tipton K, Cassels B
      Monoamine oxidase inhibitory effects of some 4-aminophenethylamine derivatives
      Biochem Pharmacol, 47: 1365-1371 (1994)

    • Herrera-Marschitz M, Loidl CF, You ZB, Andersson K, Silveira R, O'Connor W, Goiny M
      Neurocircuitry of the basal ganglia studied by monitoring neurotransmitter release: effects of intracerebral and perinatal asphytic lesions
      Mol Neurobiol, 8: 1-9 (1994)

    • Dajas F, Silveira R
      Neurotoxins in Neurobiology: an overview
      In: K. Tipton and F. Dajas (Eds.), Neurotoxins in Neurobiology, pp. 1-26, Chichester, U.K.: Elis Horwood (1994)

    • You ZB, Herrera-Marschitz M, Brodin E, Meana J, Morino P, Hokfelt T, Silveira R, Goiny M, Ungerstedt U
      On the origin of striatal cholecystokinin (CCK) release: studies with in vivo microdialysis
      J Neurochem, 62: 76-85 (1994)

    • Wolfman C, Abó MV, Calvo D, Medina J, Dajas F, Silveira R
      Recovery of central noradrenergic neurons one year after the administration of the neurotoxin DSP4
      Neurochem Int, 25: 395-400 (1994)

    • Capurro A, Reyes M, Ardanaz JL, Silveira R, Macadar O
      Serotonergic control of electric organ discharge in Gymnotus carapo. Role of 5-HT2A-2C receptor subtypes
      Comp Biochem Physiol A, 109: 583-591 (1994)

    • Viola H, Wasowski C, Levi M, Wolfman C, Silveira R, Dajas F, Medina J, Paladini A
      Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptor-ligand with axiolytic effects
      Planta Med, 61: 11-14 (1995)

    • Bolioli B, Blasina F, Silveira R, Dajas F
      Neonatal acetylcholinesterase inhibition by fasciculin 2 in rats: a model for the study of central nervous system development?
      Toxicon, 33: 909-916 (1995)

    • Monti J, Jantos H, Silveira R, Reyes M, Scorza C, Prunell G
      Sleep and waking in 5,7-DHT-lesioned or (-)pindolol-pretreated rats after administration of buspirone, ipsapirone or gepirone
      Pharmacol Biochem Behav, 52: 305-312 (1995)

    • Silveira R, Reyes M, Scorza C, Romero V, Medina J, Andrews D, Nichols E, Cassels B
      (+-)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2) a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin-1A receptors.
      N S Arch Pharmacol, 354: 579-585 (1996)

    • Scorza C, Reyes M, Silveira R, Viola H, Medina J, Viana JB, Zangrossi H, Graeff F
      Behavioral effects of the putative anxiolytic (±)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2) in rats and mice
      Pharmacol Biochem Behav, 54: 355-361 (1996)

    • Viana JB, Silveira R, Graeff FG
      d-Fenfluramine selectively releases 5-HT from terminals of the dorsal Raphe nucleus
      Braz J Med Biol Res, 29: 639-642 (1996)

    • Herrera-Marschitz M, Goiny M, Meana J, Silveira R, Godukhin O, et al.
      On the origin of extracellular glutamate levels monitored in the basal ganglia or the rat by in vivo micodialysis
      J Neurochem, 66: 1726-1735 (1996)

    • Reyes M, Scorza C, Romero V, Silveira R, Medina J, Andrews D, Nichols E, Cassels B
      (+/-)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2) a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin-1A receptors
      N S Arch Pharmacol, 354: 579-585 (1996)

    • Capurro A, Reyes M, Olazábal D, Perrone R, Silveira R, Macadar O
      Agressive behavior and jamming avoidance response in the weakly electric fish Gymnotus carapo. Effects of 3,4-methylenedioxymethamphetamine (MDMA)
      Comp Biochem Physiol A, 118: 831-840 (1997)

    • Meana J, Herrera-Marschitz M, Goiny M, Silveira R
      Modulations of catecholamine release by alpha2-adrenoceptors and I-imidazoline receptors in rat brain
      Brain Res, 744: 216-226 (1997)

    • Scorza C, Carrau C, Silveira R, Zapata R, Cassels B, Reyes M
      Monoamine oxidase inhibitory properties of some methoxilated and alkyltio amphetamine derivatives. Structure-activity relationships
      Biochem Pharmacol, 54: 1361-1369 (1997)

    • Lagos P, Scorza C, Monti JM, Jantos H, Reyes-Parada M, Silveira R, Ponzoni A
      Effects of the D3 preferring dopamine agonist pramipexole on sleep and waking, locomotor activity and striatal dopamine release in rats
      Eur Neuropsychopharmacol, 8(2): 113-20 (1998)

    • Dajas-Bailador FA, Asencio M, Bonilla C, Scorza MC, Echeverry C, Reyes-Parada M, Silveira R, Protais P, Russell G, Cassels BK, Dajas F
      Dopaminergic pharmacology and antioxidant properties of pukateine, a natural product lead for the design of agents increasing dopamine neurotransmission
      Gen Pharmacol, 32: 373-379 (1999)

    • Monti JM, Ponzoni A, Jantos H, Lagos P, Silveira R, Banchero P
      Effects of accumbens m-chlorophenylbiguanide microinjections on sleep and waking in intact and 6-hydroxydopamine-treated rats
      Eur J Pharmacol, 364(2-3): 89-98 (1999)

    • Scorza MC, Silveira R, Nichols DE, Reyes M
      Increase of extracellular 5-HT in the dorsal hippocampus of rats after acute administration of 5-HT releasing agents. Implication for the development of novel antidepressants with a short onset of action
      Neuropharmacology, 33: 1055-1061 (1999)

    • Lamprea M, Cardenas F, Silveira R, Morato S, Walsh T
      Dissociation of memory and anxiety in a repeated elevated plus maze paradigm: forebrain cholinergic mechanisms
      Behav Brain Res, 117: 97-105 (2000)

    • Gevaerd M, Takahashi R, Silveira R, Da Cunha C
      Caffeine reverses the memory disruption induced by intra-nigral MPTP-injection in rats
      Brain Res Bull, 55: 101-106 (2001)

    • Silveira M, Zangrossi H, de Barros Viana M, Silveira R, Graeff F
      Differential expression of Fos protein in the rat brain induced by performance of avoidance or escape in the elevated T-maze
      Behav Brain Res, 126: 13-21 (2001)

    • Lagos P, Duran R, Cerveñansky C, de Freitas C, Silveira R
      Identification of hemolytic and neurotoxic activities in the venom of the sea anemone Bunodosoma cangicum
      Braz J Med Biol Res, 34-7: 895-902 (2001)

    • Bortolozzi A, Evangelista A, Dajas F, Dufferd R, Silveira R
      Intracerebral administration of 2,-diclorophenoxyacetic acid induces behavioural and neurochemical alterations in the rat brain
      Neurotoxicology, 22(2): 221-232 (2001)

    • Da Cunha C, Gevaerd M, Vital MA, Miyoshi E, Andreatini R, Silveira R, et al.
      Memory disruption in rats with nigral lesions induced by MPTP: a model for early Parkinson's disease amnesia
      Behav Brain Res, 124: 9-18 (2001)